Estudio de línea base de comunidades: Informe de Análisis del sitio para Cauca – Los Cerrillos, Colombia (CO01)

Se presenta el informe del estudio de línea de base del TeSAC (Territorio Sostenible Adaptado al Clima) de la comunidad de Los Cerrillos, desarrollado entre 15 al 23 de noviembre de 2014 en el sitio CCAFS Cauca-Los Cerrillos (CO 01), Colombia. La cultura agrícola del monocultivo de café y caña ha generado una dependencia económica y de desarrollo que ante las crisis climáticas o de precios podría poner en peligro la seguridad alimentaria de la comunidad. La falta de diversificación de la producción y la generación de alternativas agro empresariales más rentables hace que los jóvenes inicien una migración a las ciudades poniendo en peligro la cultura rural del territorio. Aunque se nota un aumento en las coberturas boscosas la ausencia de la autoridad ambiental competente y el desconocimiento de estrategias para la conservación pone en peligro el mantenimiento de los bosques y la conservación de las aguas, en especial por la potencial amenaza de la minería a la cual la comunidad hasta ahora se ha opuesto. Durante los diferentes ejercicios se identificaron 38 organizaciones que desarrollan acciones en el territorio, de las cuales 23 se relacionan con seguridad alimentaria, 10 con crisis por alimentos y 18 en manejo de recursos naturales. Esto muestra que las crisis no han sido recurrentes, pero que existe una gran preocupación por la seguridad alimentaria y el manejo de los recursos naturales. Se resalta la importancia de tres organizaciones que son el eje de la articulación: Junta de Acción Comunal Los Cerrillos, Comité de Cafeteros del Cauca y la UMATA, que Dieciocho de las 19 organizaciones que operan en la comunidad se dedica a la seguridad alimentaria. No existen redes de información para la toma de sesiones agrícolas y climáticas, la comunidad culturalmente toma sus decisiones con base en señas de la naturaleza y consulta a los mayores, existe desconfianza de la información climática anunciada en la televisión. El ejercicio de visión de futuro permite notar el interés de la comunidad por mantener su tradición de agricultores, mejorar su infraestructura, cualificar la productividad y producción, conservar los recursos naturales, mejorar la equidad de género y prepararse para afrontar la variabilidad y cambio climático

Strategies for electricity supply in the province of Mendoza : a multi-attribute trade-off analysis application

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1996.Includes bibliographical references (leaves 80-81).by Luis A. Paz-Galindo.M.S

Storage and capacity rights markets in the natural gas industry

This dissertation presents a different approach at looking at market power in capacity rights markets that goes beyond the functional aspects of capacity rights markets as access to transportation services. In particular, this dissertation analyzes the role of storage in limiting the ability of pipelines to extract monopoly rents. The first two chapters present a model that show storage, by intertemporally linking markets, as introducing the pipeline in the valley as a competitor to the pipeline in the peak. As such, storage limits the ability of the pipeline to price monopolistically. This competitive effect is present although the pipeline retains 100% market share. It is thus important that regulators understand that focusing on concentration indices as a measure of market power overestimates the extent to which pipeline can extract monopoly rents. This dissertation also focuses on the role of contracts in capacity rights markets. Contracts play a dual role. They not only allow for a stronger competitive effect of storage but they can also lead to more efficient levels of pipeline investments as they can allocate risks more efficiently and can solve the information asymmetry problems. In this sense, contracts and storage should be seen as substitutes to market mechanisms when markets fail. In some instances, this dual role of contracts can be conflicting. Regulators need to understand this dual role of contracts in order to use it as a tool for achieving efficiency in capacity rights markets

Pan-cancer efficacy of pralsetinib in patients with RET fusion–positive solid tumors from the phase 1/2 ARROW trial

Pharmacodynamics; Prognostic markers; Target validationFarmacodinámica; Marcadores pronósticos; Validación de objetivosFarmacodinàmica; Marcadors pronòstics; Validació d'objectiusOncogenic RET fusions occur in diverse cancers. Pralsetinib is a potent, selective inhibitor of RET receptor tyrosine kinase. ARROW (NCT03037385, ongoing) was designed to evaluate pralsetinib efficacy and safety in patients with advanced RET-altered solid tumors. Twenty-nine patients with 12 different RET fusion–positive solid tumor types, excluding non-small-cell lung cancer and thyroid cancer, who had previously received or were not candidates for standard therapies, were enrolled. The most common RET fusion partners in 23 efficacy-evaluable patients were CCDC6 (26%), KIF5B (26%) and NCOA4 (13%). Overall response rate, the primary endpoint, was 57% (95% confidence interval, 35–77) among these patients. Responses were observed regardless of tumor type or RET fusion partner. Median duration of response, progression-free survival and overall survival were 12 months, 7 months and 14 months, respectively. The most common grade ≥3 treatment-related adverse events were neutropenia (31%) and anemia (14%). These data validate RET as a tissue-agnostic target with sensitivity to RET inhibition, indicating pralsetinib’s potential as a well-tolerated treatment option with rapid, robust and durable anti-tumor activity in patients with diverse RET fusion–positive solid tumors.The authors would like to thank the patients, their families and all investigators involved in this study. V.S. is an Andrew Sabin Family Foundation Fellow at The University of Texas MD Anderson Cancer Center. V.S. acknowledges support of the Jacquelyn A. Brady Fund. V.S. is supported by US National Institutes of Health grants R01CA242845 and R01CA273168. MD Anderson Cancer Center Department of Investigational Cancer Therapeutics is supported by the Cancer Prevention and Research Institute of Texas (RP1100584), the Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy (1U01 CA180964), a National Center for Advancing Translational Sciences grant (UL1 TR000371) and the MD Anderson Cancer Center Support grant (P30 CA016672). Medical writing support, including assisting authors with the development of the outline as well as initial draft and incorporation of comments, was provided by N. Tracey and W. Wheddon; editorial support, including submission, was provided by E. Sims and T. Taylor, all of Paragon (Knutsford, United Kingdom), supported by Blueprint Medicines, according to Good Publication Practice guidelines. The sponsor was involved in the study design and collection, analysis and interpretation of data, as well as data checking of information provided in the article. However, ultimate responsibility for opinions, conclusions and data interpretation lies with the authors. E.G. is supported by the Caixa Research Advanced Oncology Research Program (supported by Fundació La Caixa, LCF/PR/CE07/50610001). E.N. is supported by the Carlos III National Health Institute grant (PI21/00789) and Horizon 2020 (H2020-SC1-2019-Single-Stage-RTD). M. Schuler is supported by the Oncology Center of Excellence Grant/German Cancer Aid (70112273) and the German Cancer Consortium, partner site: University Hospital Essen (BMBF 613-71043-1). G.C. is supported by an OPTIMA (optimal treatment for patients with solid tumors in Europe through artificial intelligence) grant (101034347). The ARROW study (NCT03037385) was supported by Blueprint Medicines and F. Hoffmann-La Roche

Valoración del efecto de la calcitonina en la consolidación de la fractura de Colles

Se estudian cuarenta pacientes en que se ha producido una Fractura de Epífisis Distal de Radio (Fractura de POUTEAU-COLLES) en pacientes mayores de cincuenta años, con signos de osteoroporosis. Se han hecho dos grupos aleatorios de veinte pacientes. El grupo A se ha tratado con un programa de calcitonina y calcio que cubre los tres primeros meses. El grupo B es tratado exclusivamente con calcio, por igual período. En ambos la reducción e inmovilización sigue los mismos criterios. Se evalúan los resultados, observando que el grupo A presenta menos secuelas dolorosas.The authors have studied 40 patients with fracture of distal epiphysis of radius (POUTEAU-COLLES' fracture) all of them fifty years old with signs of osteoporosis. They have made two groups of patients (20 every one). The group A has been treated with a program of calcitonin and calcium during three months. The group B has been treated only with calcium, three months, as well as the other group. Both groups have the same criterion of reduction and inmovilization. The evaluation of results in the first group showed less painful consequences

Linear Strain Tensors on Hyperbolic Surfaces and Asymptotic Theories for Thin Shells

We perform a detailed analysis of the solvability of linear strain equations on hyperbolic surfaces. We prove that if the surface is a smooth noncharacteristic region, any first order infinitesimal isometry can be matched to an infinitesimal isometry of an arbitrarily high order. The implications of this result for the elasticity of thin hyperbolic shells are discussed

Randomized, Double-Blind, Phase II Trial Comparing Gemcitabine-Cisplatin plus the LTB4 Antagonist LY293111 versus Gemcitabine-Cisplatin plus Placebo in First-Line Non–Small-Cell Lung Cancer

Introduction:In this phase II study, patients with stage IIIB/IV non–small-cell lung cancer were randomly assigned (1:1:1) to receive LY293111 (200 mg twice daily [200 LY293111] or 600 mg twice daily [600 LY293111]) or placebo for 7 days, followed by concurrent cisplatin (75 mg/m2; day 1) and gemcitabine (1250 mg/m2; days 1 and 8), every 21 days.The primary endpoint was progression-free survival, (PFS), with 75% power to detect 33% improvement compared with placebo (5 months).Methods:Of 200 randomized patients, 195 were treated. Demographics were well balanced across treatment arms: 65% of the patients were men; median age was 62 years; 85% had stage IV disease; and patients had an Eastern Cooperative Oncology Group performance status of 0 (36%) or 1 (64%).Results:The most frequent study drug–related toxicities were nausea, vomiting, and fatigue. Response rates were similar across treatment arms (200 LY293111: 20%; 600 LY293111: 25%; placebo: 31%).Conclusions:Median PFS (95% confidence interval) was not significantly different across treatment arms (200 LY293111: 4.6 months [3.2–5.0]; 600 LY293111: 5.6 months [4.1–6.8]; placebo: 6.0 months [5.2–7.5]). LY293111 combined with gemcitabine-cisplatin did not increase median PFS compared with placebo plus gemcitabine-cisplatin in patients with non–small-cell lung cancer

Quasiprobability distribution functions for periodic phase-spaces: I. Theoretical Aspects

An approach featuring $s$-parametrized quasiprobability distribution functions is developed for situations where a circular topology is observed. For such an approach, a suitable set of angle-angular momentum coherent states must be constructed in appropriate fashion.Comment: 13 pages, 3 figure